Too Long; Didn't Read
At eBay we are using <a href="http://markojs.com/" target="_blank">Marko</a> to render over a billion requests every day and this has required us to finely tune Marko, our open source UI library. We have heavily optimized Marko for fast rendering, <a href="http://www.ebaytechblog.com/2014/12/08/async-fragments-rediscovering-progressive-html-rendering-with-marko/" target="_blank">advanced performance techniques</a> and to achieve a minimal page weight (~10kb gzipped). Performance is only one concern because we have also had to scale Marko to support development across hundreds of teams in a way that allows developers to efficiently create maintainable and robust web apps.