Too Long; Didn't Read
Combinatorial mutagenesis (CM) is an established approach to protein <a href="https://hackernoon.com/tagged/engineering" target="_blank">engineering</a> in pharma and industrial settings. As an extremely laborious process, <a href="https://hackernoon.com/tagged/cm" target="_blank">CM</a> relies on human intuition (rational engineering inspired by existing 3D structures of a protein target) or environmental pressure (directed evolution) to guide the development of new functional variants (mutants) of desired protein target with the goal of enhancing specific property; e.g. thermal stability, solubility or aggregation propensity.