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Python Basics: File Handling is a basic tutorial on how to open, read, manipulate, and save files in python. You can open a file in python in different modes such as reading mode, writing mode, appending mode, binary mode, and etc. You can also use the open() function to read a file and manipulate it in just one line of code. For instance, let’s try reading quotes.txt from a file which contains quotes as shown below;. After each line, we print a line of stars on a specific specific line;.