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When you choose an operating system for medical devices, you can easily get confused by the wide choice of options. They may differ in the nature of their source code, cost, size, architecture, performance, and area of application. In this article, we would like to take a look at the options of the most popular open-source and closed-source OS families. Both operating systems have a broad range of abilities and features that allow for their use in medical equipment. There is no absolute answer to the question of what is better: Linux or Windows 10 IoT.