SmileSIM

Using alternative SMILES canonicalizations, CheSS leverages ChemBERTa embeddings to find structurally distinct but functionally similar molecules.

Chemical Language Models Improve Similarity Search With SMILES Variations

Tokenization differences in CheSS searches affect molecular embeddings, revealing nuanced relationships and enhancing chemical similarity searches.

SMILES Variations Influence Chemical Search Behavior and Functional Discovery

“He spoke to me once of his hatred for our father and his fear that at an extreme moment ... at a moment of fury, he might perhaps murder him.”

Fortune Smiles On Mitya

A very good friend of mine has heard me tell many a tale of trips in which I have been given free drinks, gratis hotel and car rental upgrades and various <a href="https://hackernoon.com/tagged/travel" target="_blank">travel</a> freebies. However, without experiencing my stories first hand, he always suspected there was a degree of embellishment involved to make my stories a bit more entertaining.

The Secret To Getting Free Drinks, Upgrades And Genuine Smiles When You Travel

Hawk Carse endures the harrowing Visi-Screen ordeal, witnessing Eliot Leithgow strapped to an operating table under Dr. Ku Sui’s cruel experiments. 

The Visi-Screen Ordeal

Read Chapter I of The Affair of the Brains (1932) on HackerNoon, where Hawk Carse hunts Ku Sui in a classic pulp sci-fi showdown.

Off to the Rendezvous

Vibe coding promises fast AI-built apps—but rising bugs, code churn, and technical debt show why prototypes aren’t products.

Vibe Coding is a Technical Debt Factory

Why communities are driven by the 1%, not 10%, and how to adapt - and thrive.

Is the 90/10 Rule Dead? How the 1% Drives 99% of Community Growth

Stop tying your worth to outcomes you can’t control. Break free from imposter syndrome and build a life on values, not a rigged scoreboard.

The Prison You Build While Trying to Prove You Belong

They called CryptoPunks an experiment that became a religion. Doginal Dogs started as a free mint with no roadmap and no runway. 

Beyond Punks: How Doginal Dogs Engineered a Movement

Jogg AI's advanced AI technology ensures that every word matches perfectly with lip movements, creating videos so natural viewers won't believe they're automate

Transform Static Images Into Dynamic Videos With JoggAI’s Talking Photo

A story of how nets purchased in Europe saved lives of Ukrainian soldiers.

These Volunteers Turned Bird Nets Into Anti-Drone Shields

In the Bitcoin Verse, Spidergirl versus an evil vampire cyborg.

Slaying The Bitcoin Vampire

ChatGPT wrote and optimized copula model code, showing how prompt tweaks impact success—with no human code written.

How ChatGPT Helped Code a Copula Model Without Human Input

Pair programming with ChatGPT shows both promise and pitfalls—from quick solutions to occasional errors and reasoning flaws. Here's what we learned.

What Works (and Doesn’t) When Coding with ChatGPT

ChatGPT helps debug, optimize, and parallelize statistical code across languages like R, Python, and MATLAB—with insights into prompt engineering.

Debugging Copulas and Speeding Up Simulations with AI

ChatGPT stumbles on copula sampling but learns to correct errors, showing potential in coding and understanding complex statistical concepts.

When AI Gets It Wrong—and Then Gets It Right

We test ChatGPT’s ability to code the Clayton copula density and perform ML estimation. Results vary—great at general tasks, weak at symbolic math reasoning.

ChatGPT, Symbolic Math, and the Struggle for Accuracy

We test ChatGPT as a pair programming partner, evaluating its code accuracy, response consistency, and understanding of complex statistical models.

Testing ChatGPT as a Pair Programming Partner

Simulating a real-world workflow, we test how ChatGPT solves technical tasks step-by-step without expert programming knowledge.

Exploring AI Memory, Limitations, and Workarounds in Practice

ChatGPT helps build a full Monte Carlo simulation for copula modeling—no human coding needed, just natural language and math prompts.

Using AI to Build a Monte Carlo Simulation

How to deeply and actively listen is a transformative skill that improves relationships, reduces conflict, and helps people grow.

Everyone Thinks They’re a Good Listener — Most Are Just Waiting to Talk

ChatGPT aids drug discovery with idea generation, molecule design, and DDI prediction—but fine-tuning, prompting, and expert input are still essential

Can ChatGPT Accelerate Drug Discovery? Here's What the Science Says

People don't argue online logically. They do it for engagement, enjoyment, or accountability. There are 4 arguer types: Philosopher, Amateur, Troll, Manipulator

SMILESIM

smilesim.com

Since 2021

SmileSIM's stories on HackerNoon

Chemical Language Models Improve Similarity Search With SMILES Variations

SMILES Variations Influence Chemical Search Behavior and Functional Discovery

Fortune Smiles On Mitya

The Secret To Getting Free Drinks, Upgrades And Genuine Smiles When You Travel

The Visi-Screen Ordeal

Off to the Rendezvous

Vibe Coding is a Technical Debt Factory

Is the 90/10 Rule Dead? How the 1% Drives 99% of Community Growth

The Prison You Build While Trying to Prove You Belong

Beyond Punks: How Doginal Dogs Engineered a Movement

Transform Static Images Into Dynamic Videos With JoggAI’s Talking Photo

These Volunteers Turned Bird Nets Into Anti-Drone Shields

Slaying The Bitcoin Vampire

How ChatGPT Helped Code a Copula Model Without Human Input

What Works (and Doesn’t) When Coding with ChatGPT

Debugging Copulas and Speeding Up Simulations with AI

When AI Gets It Wrong—and Then Gets It Right

ChatGPT, Symbolic Math, and the Struggle for Accuracy

Testing ChatGPT as a Pair Programming Partner

Exploring AI Memory, Limitations, and Workarounds in Practice

Using AI to Build a Monte Carlo Simulation

Everyone Thinks They’re a Good Listener — Most Are Just Waiting to Talk

Can ChatGPT Accelerate Drug Discovery? Here's What the Science Says

What If There Was a Right Way to Argue Online?

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