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In this article, we will learn to remove commas from strings using the Python program. We will create a program using different methods and using different functions. The program will remove the first comma from the string using replace() function. Remove n number of commas using the remove() function of Python. The function is also used to remove a specific number of substrings from a given string in Python programming. The result is a string with no commas removed from the given string and the number of comma removed.