On 29 November 2021, Twitter CEO Jack Dorsey announced that he was resigning from Twitter and that Agrawal would be the new CEO of the company. Agrawal has worked on efforts to let users send tips using bitcoin and other cryptocurrencies, and recently hired the head of a new dedicated crypto team. He also oversees the company's Bluesky project, which aims to build decentralized social networking software on which any number of platforms could run." In an interview with MIT Technology Review in November 2020, when asked about balancing the protection of free speech as a core value and the endeavor to combat misinformation, Agrawal said: "Our role is not to be bound by the First Amendment, but our role is to serve a healthy public conversation … focus less on thinking about free speech, but thinking about how the times have changed."